KMID : 1100220150140010017
|
|
Dementia and Neurocognitive Disorders 2015 Volume.14 No. 1 p.17 ~ p.23
|
|
Anatomical Correlates of the ¡°Closing-In¡± Phenomenon
|
|
Kwon Se-Yoon
Lee Eek-Sung Hong Yun-Jeong Lim Sung-Chul Ahn Kook-Jin Yoon Bo-Ra Shim Yong-Soo Yang Dong-Won
|
|
Abstract
|
|
|
Background and Purpose : The ¡°closing-in¡± phenomenon refers to the tendency to copy near or overlap a model while performing figure-copying tasks. The mechanisms underlying the closing-in phenomenon have not been fully elucidated, and previous studies only investigated the mechanisms through neuropsychological tests. We investigated the neuroanatomical correlates of the closing-in phenomenon using voxel-based morphometry (VBM).
Methods : Thirty-eight patients diagnosed with probable Alzheimer¡¯s disease (AD) and 21 normal controls were included. All subjects underwent neuropsychological testing to diagnose dementia and magnetization prepared rapid acquisition gradient echo brain magnetic resonance imaging for the voxel-based statistical analysis. The subjects were asked to copy the modified Luria¡¯s alternating squares and triangles to quantify the closing-in phenomenon. We applied SPM8 for the VBM analysis to detect gray matter loss associated with the closing-in phenomenon.
Results : The patients with probable AD showed a higher closing-in score than that of the normal control subjects (p<0.0001). The VBM analysis revealed more parietal and temporal atrophy in the patients with AD than that in the normal control group. Moreover, atrophy of the orbito-frontal area was associated with the closing-in phenomenon.
Conclusions : The closing-in phenomenon is dysfunction while performing figure-copying tasks and is more common in patients with AD. The analysis of the orbito-frontal area, which is associated with inhibiting primitive reflexes, revealed that the closing-in phenomenon is an imitation behavior commonly observed in patients with frontal lobe damage.
|
|
KEYWORD
|
|
closing-in phenomenon, voxel-based morphometry analysis, orbitofrontal, Alzheimer¡¯s disease.
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|